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May 26, 2020
Todos los Productos de SAi Flexisign Pro Crear desde 0, Your SAi Flexisign Pro evaluation.Ipilimumab and nivolumab for advanced or metastatic melanoma.
CheckMate 066 and 067 studies are phase III randomised, open-label studies of the efficacy and safety of ipilimumab plus nivolumab compared with ipilimumab plus placebo in participants with metastatic melanoma. The primary endpoint for both studies is the overall survival rate. The CheckMate 067 study will enroll 1500 participants, of which 750 will receive ipilimumab alone and 750 ipilimumab plus nivolumab. The CheckMate 066 study will enroll approximately 1000 participants, of which 500 will receive ipilimumab alone and 500 ipilimumab plus nivolumab. Subcutaneous doses of either one or two of ipilimumab (10 mg per kilogram of bodyweight) and nivolumab (3 mg per kilogram of bodyweight) were administered every 3 weeks for 4 doses. CheckMate 067 participants will also receive nivolumab every 2 weeks for 2 cycles (infusion days 1 and 15) as an investigational new drug. The CheckMate 066 study will investigate the efficacy of ipilimumab plus nivolumab compared with ipilimumab alone in participants with melanoma. The CheckMate 066 study will also evaluate the safety and tolerability of these compounds. The CheckMate 067 study will investigate whether combining nivolumab and ipilimumab may improve overall survival compared with ipilimumab alone in participants with melanoma. The CheckMate 067 study will also evaluate the safety and tolerability of these compounds.The present invention relates to electric power cables and, in particular, to cables using a heat shrink sleeving to protect the cables when the cables are connected in a cable harness.
The use of heat shrink sleeving to protect and insulate power cables is well known in the industry. Generally, a heat shrink sleeve is applied over a length of cable and heat is applied to the sleeve, thereby shrinking the sleeve over the cable. Typically, the heat shrink sleeve is applied to the cables after the power cables have been connected in a cable harness with another cable or some other piece of electrical equipment. The power cables are then connected to the
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